Retatrutide (20 mg vial) dosing protocol
Educational overview — not medical advice
Reconstitution (20 mg vial)
Add 2.0 mL bacteriostatic water to a 20 mg lyophilised vial → about 10.0 mg/mL.
At 10.0 mg/mL, 1 U on a U‑100 insulin syringe = 0.01 mL ≈ 100 mcg.
Weekly titration (same mg/week targets, different volumes)
Use the same milligram schedule as the 5 mg vial guide on this site (e.g. 2 → 4 → 6 → 8 mg/week with 4‑week steps when tolerated). Only the injected volume changes because concentration is 2× higher than 5 mg/mL.
| Phase | Weekly dose | Syringe units at 10 mg/mL (mL) |
|---|---|---|
| Weeks 1–4 | 2 mg | 20 units (0.20 mL) |
| Weeks 5–8 | 4 mg | 40 units (0.40 mL) |
| Weeks 9–12 | 6 mg | 60 units (0.60 mL) |
| Weeks 13+ | 8 mg | 80 units (0.80 mL) |
For >10 mg/mL-equivalent weekly totals that require >1.0 mL per injection, many protocols split into two SC injections the same day at different sites.
Storage & stability
Lyophilised: −20 °C (or supplier guidance). After reconstitution: 2–8 °C, protect from light; commonly ~4 weeks unless your COA says otherwise.
Disclaimer
Educational only; not medical advice. Retatrutide is investigational in many regions.